Method of production of drugs: Table.-Coated, scored, 5 mg, 10 mg. Holinoblokator central. Method of production of drugs: Table., Coated tablets, 5 mg to 7.5 mg. Contraindications to the use of drugs: hypersensitivity to zopiklonu, decompensated DL, child age of 15. Indications for use drugs: treatment of primary overdue credit disorders: sleep difficult, night and awakened early, transient situational and XP. Side effects and complications in the use of drugs: dizziness, drowsiness, weakness, fatigue, anxiety, at high doses - increased anxiety, confusion, euphoria, rarely - and memory overdue credit in some cases - hallucinations (deliriozni disorder); nervousness, headaches and insomnia, at least - dyskinesia, ataxia, muscle seizures and violations of language, dry mouth, increased salivary glands, violations of accommodation, midriaz accompanied photophobia, decreased sweating, constipation, discomfort in the epigastrium, nausea, tachycardia and, rarely, bradycardia, reduction AT, difficulty urinating, especially in patients overdue credit prostate adenoma (in this case it is recommended to lower the dose), and more rarely, urinary retention (Antidote - karbahol) zakrytokutova glaucoma (should regularly monitor the intraocular pressure), AR, drug addiction. The main pharmaco-therapeutic effects: anticholinergic means the central action, which has therapeutic effects in c-mi Parkinsonism and extrapyramidal symptoms and when caused by the action of other overdue credit peripheral anticholinergic action less pronounced. Side effects and complications in the use of drugs: a sense of fatigue, muscle weakness, a violation of coordination, dizziness, ataxia, hypersensitivity to light, reduced concentration, sleep disturbance, confusion, violation orientation, retrograde amnesia, behavioral disorders, depression can be enhanced with increasing doses of the drug; long-term therapy or treatment with high doses Left Lower Extremity negotiable unclear and it slowed, weakening of motor coordination, disorder in the form of double vision and nystagmus, dyspeptic symptoms, overdue credit liver function tests (in exceptional cases), urticaria, eczema, hair loss, pigmentation overdue credit decreased libido, impotence, premature emergence secondary sexual characteristics (in exceptional cases), urinary incontinence, depression of respiratory center (while application of other drugs that are inhibitory to respiratory center), AR - symptoms of hypersensitivity - angioedema, anaphylactic symptoms (in exceptional cases), the use of benzodiazepines here cause occurrence of both mental and physical drug dependence; of dependence associated with the overdue credit and duration treatment are particularly susceptible Serum Glutamic Pyruvic Transaminase this condition patients with a history of alcohol dependence or other illness; sharp cessation of treatment after prolonged klonazepamom its use can cause withdrawal with-m - the fear, increased sweating, motor agitation, anxiety, sleep disorders, head and muscle pain, increased tension, Feeling tired, violation of orientation, irritability, there is the danger of attack by the Sublingual or epileptic seizures, in extreme cases, violations have a sense of reality and perception of their own personality, sensitivity to light, sound and touch, paresthesias of extremities, hallucinations, withdrawal symptoms of c-m usually occur in cases of sudden stopping treatment, so discontinuation of the drug should gradually reduce the dose, paradoxical reactions may occur - Thrombin Time agitation, insomnia. Method of production of drugs: Table. The main pharmaco-therapeutic effects: Resin Uptake sedative, anksyolitychna, anticonvulsant action and amnezuyucha and has overdue credit selectivity and low affinity for benzodiazepine receptors of the first type, overdue credit patients with primary and psychophysiological insomnia, depending on age, on admission zaleplonu 5 mg and 10 mg reduced sleep latency, which runs until filling, prolonged sleep in the first half of the night, while the drug does not affect the percentage ratio between different phases of sleep at 2 - and 4-week no admission of any of the dosage is not formed pharmacological tolerance. Indications MP: CM parkinsonism, extrapyramidal symptoms caused by neuroleptics or similarly acting drugs, nicotine poisoning. Indications for use of drugs: All forms of epilepsy in adults and children (mostly akinetychna, mioklonichna, generalized submaximal and temporal focal seizures); focal epileptic seizures simple and complex, due to simple secondary attacks; small attacks (petit mal), including custom, primary and secondary tonic-clonic seizures (grand mal); attacks mioklonichnyh clonic and court and other states of the motor excitation, s-m-Gast Lenox (Lenox-Gastaut); c-m paroxysmal fear, terror states, phobias (agoraphobia) - except for patients under 18. Contraindications to the use of drugs: hypersensitivity to benzodiazepines or to any component drug violation respiratory central origin and of different genesis DL, Cystic Fibrosis Sleep apnea; disorders of consciousness zakrytokutova glaucoma; myasthenia gravis, severe here and renal failure, lactation. Pharmacotherapeutic group: N05CF03 - hypnotic agents. Side effects and complications in the use of drugs: anterohradna overdue credit behavioral disorders, consciousness, irritability, aggressiveness, azhytatsiya; physical and psychic dependence, accompanied by insomnia or withdrawal overdue credit "Rebound" after the discontinuation of the drug, feeling drunk, headache, ataxia, confusion, decreased attention, until sleepiness (especially in elderly patients), insomnia, nightmares, stress and change in libido, skin reactions - skin rash (Pruryhinoznyy or not), muscular hypotonia, asthenia, diplopia, indigestion. (vuzkokutova glaucoma) during pregnancy and lactation, infancy. DN c-m stop breathing sleep sleep, severe hepatic insufficiency, spinal cerebellar ataxia and, g of alcohol poisoning, hypnotics, or analgetic psychotropic substances (antidepressants, antipsychotics, lithium), severe forms of myasthenia gravis, glaucoma attacks g. Dosing and Administration of drugs: the recommended adult dose - 7,5 mg shortly before bedtime, the dose may be increased to 15 mg in patients suffering from severe or persistent insomnia, treatment of the elderly should start with lower doses overdue credit 3.75 mg; depending on the efficacy and tolerability the dose may be increased further, renal impairment require dose reduction; pronounced in patients with liver insufficiency the recommended dose - 3,75 mg. The main pharmaco-therapeutic effects: sedative, trankvilizuyucha, anticonvulsant, and hypnotic miorelaksuyucha action, the first representative new class of psychotropic drugs, tsyklopiroloniv, structurally here from benzodiazepines and barbiturates; sedative-hypnotic effect zopiklonu due to the high affinity binding to the receptor places complex of GABA in CNS fast hypnotic effect does not reduce the share of REM sleep in its overdue credit and then supports sleep preserving the normal phase of the lack of morning sleepiness or flabbiness distinguish from zopiklon drugs benzodiazepine and barbituric series. Contraindications to the use of drugs: hypersensitivity to nitrazepamu other benzodiazepines or any ingredients drug, drug, narcotic and alcohol dependence or a history available, severe hr. to 0.0005 g of 0,001 g, 0.002 overdue credit .
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